O-050 The impact of embryo biopsy on obstetric and neonatal outcomes

Abstract Background Preimplantation genetic testing of embryos (PGT) was performed first in 1990 to prevent the transmission X-linked disease. Since then, technique has improved include couples who are both carriers same autosomal recessive disorder, those with balanced translocations having recurrent pregnancy loss, and women advanced maternal age at higher risk for aneuploid embryos. Originally, PGT involved biopsy polar body or one blastomere a cleavage stage embryo diagnosis. The contemporary practice involves culture blastocyst (5-7 days after fertilization), several trophectoderm cells that would become placenta, transport tissue off-site analysis, cryopreservation blastocysts until results available. A single euploid is then transferred into uterus as frozen transfer. Objective We sought determine if removal these preimplantation associated adverse obstetrical neonatal outcomes frozen-thawed transfer compared without biopsy. Further, we review other studies draw conclusions about safety practice. Study design linked assisted reproductive technology surveillance data from Society Assisted Reproductive Technology Clinic Outcome Reporting System birth certificates hospitalization discharge diagnoses Massachusetts, USA, 2014-2017, considering singleton births cycles (n = 585) no 2,191), adjusting mother’s age, race, education, parity, mass index, year, insurance, all infertility (Sites CK et al, Am J Obstet Gynecol 2021;225:285.e1-7). Results With used reference, found differences between groups respect preeclampsia, pregnancy-induced hypertension, placental disorders (placental abruption, placenta previa, accreta, increta, percreta), preterm birth, low birthweight, cesarean delivery, gestational diabetes mellitus, infant length stay delivery. Comparing our 4 transfers (Zhang WY Fertil Steril 2019, Li M 2020, Makhijani R Hum Reprod 2021, He H 2019), consistent effect on weight, diabetes, accreta. slight decrease delivery (RR 1.10, CI 1.02-1.18), reduction section 0.90, 0.82-0.99), increase intrauterine growth restriction 1.21, 1.06-1.38) reported systematic (Hou W, 2021). influenced by study (Li 2020). Conclusion Embryo appears be safe generally outcomes. There clear related placentation (preeclampsia, disorders, birthweight), Further possible indicated.